Abstract: The South Yellow Sea Basin is a multi-cycle superimposed basin consisting of the marine Mesozoic -Paleozoic basin overlaid by the continental Mesozoic-Cenozoic basin on the basis of the Presinian cratonic basement. Based on the seismic data, combined with drilling wells in its adjacent areas as well as regional geological data, the Mesozoic-Paleozoic stratigraphy and the formation and evolution of the Central Uplift of the South Yellow Sea Basin were studied. Results show that there developed rather complete Mesozoic and Paleozoic marine strata on the central uplift of the South Yellow Sea Basin, including seven seismic sequences of the Quaternary-Neogene, the Middle-Lower Triassic Qinglong Formation, the Upper Permian, the Lower Permian-Upper Devonian, the Middle-Lower Silurian, the Ordovician-Sinian and the Pre-Sinian metamorphic series. The tectonic evolution of the Central Uplift of the South Yellow Sea Basin can be divided into the following stages:the basement formation stage in Precambrian, the craton developmental stage in Sinian-Early Paleozoic, the stable platform and continental rifting stage in late Paleozoic-Middle Triassic, the formation and uplifting and erosion stage in Late Triassic-Paleogene and the depression stage in Neogene and Quaternary.