Abstract: The Mesozoic oil reservoir in the Tianhuan Syncline of the Erdos Basin is a sand lithologic reservoir on the background of low amplitude structure. Since there is little impedance difference with the surrounding rock, the reservoir prediction precision is quite low with conventional seismic reservoir prediction methods. This paper proposed a prediction technique upon the basis of seismic stratigraphy and physical property inversion,aiming at enhancing the accuracy of reservoir prediction.