Abstract: Andaman Sea Basin is a back-arc spreading basin formed by pull-apart action, whose tectonic features and evolutionary mechanism in the eastern part of the basin are essential for understanding the evolution of the Andaman Sea Basin. The structural characteristics and evolution of the eastern part of the basin are of great significance for studying the evolution of the Andaman Sea Basin and the strike-slip faults formed by the oblique subduction of the plate. The stratigraphic structure and tectonic features in the eastern Andaman Sea Basin were analyzed based on 2D and 3D seismic data, and drilling and seismic profile data. The seismic stratigraphic sequences in the eastern Andaman Sea were established. Faults were finely sculpted using automatic 3D seismic layer pickup and seismic attributes. Two major fault zones were identified and named the East Mergui Fault and the West Mergui Fault. The evolution model of the fault zone was established based on the structural analysis. The evolution of the eastern Andaman fault zone could be divided into three phases: the strike-slip and strong extension stage in the Early Miocene, the extensional strike-slip stage in the Middle to Late Miocene, and the right-lateral strike-slip stage from the Pliocene to the present.