Abstract: The interaction of submarine pipeline, soil, and water strongly affects the stability of submarine pipeline. However, the research on the change of soil properties around submarine pipeline under wave action is insufficient. The response of excess pore water pressure under wave load and pipeline vibration was studied in a series of laboratory wave flume tests. Results show that the existence of pipeline increased the accumulative pore water pressure of soil, thus enhancing the liquefaction potential of seabed. The pipeline vibration increased the accumulation degree of excess pore water pressure. In addition, wave conditions alter the response of seabed to the excess pore water pressure, namely, the increase of wave height intensify the accumulative pore water pressure. This study provided a guide to studying the pipe–soil-mass interaction and the submarine pipeline maintenance.