Abstract: To understand the diagenetic evolution of the reservoir that is controlled by different provenance- sedimentary systems, the clastic reservoir of the Mesozoic deposits in the Eastern Depression of the North Yellow Sea Basin was anatomized. Methods of thin section identification, cathodoluminescence, and scanning electron microscope were used. Results shows that the Mesozoic reservoir in the depression is largely in the stage A of mesodiagenesis, and the main diagenesis types include compaction, cementation, replacement/alteration, and tuffaceous devitrification/dissolution. The level of compaction in the eastern region is higher than that in the southwest and northern regions. The content of carbonate cement in the northern region is much higher than that in other regions. The eastern region is characterized by tuffaceous cementation and tuffaceous devitrification; and the southwest is characterized by clay mineral cementation and obvious clay mineral transformation. The development degree of dissolution in the southwest and northern regions is higher than that in the eastern region. Comprehensive analysis shows that the reservoirs in different provenance sedimentary areas in the study area have different diagenetic characteristics and show different reservoir sequences, which affected the diagenetic evolution of the reservoirs.