Abstract: In this study, 2D multi-channel seismic data from the Huizhou Depression of the Pearl River Mouth Basin is used for prestack depth migration processing. The results are as follows: (1) After multiple iterations of speed, the break point homing of the depth domain profile is more accurate than the time migration profile, especially the structure of the middle and deep parts is more clear, the overall visual appearance of the profile becomes simple, the residual diffraction and reflection are reduced, and the image quality is obviously improved. Based on the characteristics of the depth domain of the prestack depth migration profile, it has a more definite geological implication than the time domain profile, and can more intuitively display the stratigraphic and structural information, which is conducive to the geological interpretation of seismic profiles; (2) With the deepening of exploration of oil and gas in the Pearl River Mouth Basin in South China Sea, the exploration targets have gradually changed from structural traps to lithological and stratigraphic traps. The difficulty of exploration is obviously increased. Seismic data from existing regional geological surveys are mainly based on time migration. They are deficient in imaging, fault location, resolution, and signal-to-noise ratio, and difficult to meet the actual needs in exploration. As one of the most important petroleum-bearing basins in the South China Sea, the Pearl River Mouth Basin is particularly important to carry out seismic exploration upon new technology such as pre-stack depth migration.