Abstract: Upon the basis of prestack time migration seismic data,coherent body, ant body and reservoir physical factors are applied to make reservoir prediction for the deposits from the Hezhou Formation of Lower Carboniferous to the Qixia Formation of the lower Permian at the Laoshan Uplift of the South Yellow Sea. Prediction results show that there are several sets of reservoirs in the studied sequence. Reservoir cracks are developed and distributed under the control of faults and tectonic extrusive deformation.There are more cracks in the northern fault zone and southern extrusive zone. The prediction based on the integrated response of reservoir shows that the most favorable reservoir is developed in the southern part of the uplift, mainly concentrated in the extrusive anticline zones and fault zones.The reservoir prediction results have provided a strong geological basis for the evaluation of the Laoshan Uplift and favorable target areas, and the methods used in the case are proven effective.