Abstract: Exploration of the Neogene shallow-water delta plays an important role in the exploration of oil and gas reservoirs in Bohai Sea. The shallow-water delta of the lower member of Neogene Minghuazhen Formation in Bonan area was studied, from which 17 paresequencce sets were recognized based on the comprehensive analysis of drilling, logging, cores, and seismic data; and a high-frequency sequence stratigraphic framework was established. Typical lithofacies were selected to extract appropriate parameters, and seismic forward modeling was conducted to establish the quantitative relationship between amplitude and sand content. Finally, based on the seismic sedimentology method, the quantitative prediction of sandstone was carried out based on the quantitative relationship between sandstone percentage and amplitude. Results revealed an obvious positive correlation between sand content and amplitude, and it has high reliability for quantitative lithology interpretation using amplitude of 3D seismic data. By using the quantitative relationship between sand content and model amplitude, the distribution of sand content under high frequency sequences in the study area can be predicted by converting root mean square amplitude into sand content value, which provides more intuitive evidence for sedimentary geomorphology and sedimentology interpretation. This research idea and technique can be extended and applied to shallow-water delta reservoir exploration.