Abstract: The Sureste Basin is located in the southern Gulf of Mexico and there is little discussion on this basin in literatures. In order to systematically study the salt related traps in this area, geologic, drilling, field and seismic data are used to systematically analyze the features, origins and spatial distribution patterns based upon basin tectonic evolution, sedimentary features and salt movement stages. In combination of exploration status, it is concluded that the Jurassic and Cretaceous anticline with salt cores in the Comalcalco Sub-bain are the most favorable prospecting target and the Salt core anticline, tensional salt draft fault block in the Oxfordian and Kimmeridgian Formations in the North of Reforma belt are the second. The study result is helpful for optimization of the exploration targets in post salt stratum of Mexico Sureste Basin.