Abstract: The Paleogene Enping Formation of the Enping Sag is the most important reservoir in the Pearl River Mouth Basin. It is hard to be predicted precisely by using conventional methods due to absence of corresponding data such drilling data which are usually unevenly distributed. Using the seismic multi-attributes analysis technique, combined with the data of well logs, core, lithology and regional geology, we made a fine interpretation of the lithofacies of the Enping Formation. The Enping Formation could be divided into three third-order sequences:PSQ1, PSQ2, and PSQ3. Within the isochronous stratigraphic framework, there are three sedimentary facies, i.e. braided river delta, fan delta and beach bar facies. The results have been tested in the hydrocarbon exploration in the Enping Sag.