Abstract: Multiple solutions remain the key problem in seismic interpretation of clastic reservoirs due to lack of high quality data. Based on the fact that the basic features of a clastic reservoir depends on its origin and sedimentary facies, we put forward a scheme for seismic data interpretation and reservoir prediction by integration of the high resolution processing and reservoir prediction technology and the combination of sedimentary evolution and reservoir prediction. Following the scheme, the problem of multiple solutions caused by lack of high resolution seismic data is solved and the interpretation accuracy for reservoir prediction is effectively improved. The results of the interpretation scheme are presented in this paper taking the clastic reservoir of the A oilfield of the Llanos basin as an example.